Joseph C. LaManna, PhD is The Jeannette M. and Joseph S. Silber Professor for the Study of Brain Sciences in the Department of Physiology & Biophysics at Case Western Reserve University. He has been a member of ISOTT since 1974 and served as Past President of the Society (2009). He is the Series Editor of the ISOTT Proceedings. He has been involved in cerebrovascular research for 40 years. His research is concerned with brain metabolism, energy and cerebral blood flow, angiogenesis and neurodegeneration. The role of these mechanisms in tissue response to pathological insults (stroke, cardiac arrest and resuscitation, hypoxia) is being actively investigated. His recent research has centered on ketones, cerebral angiogenesis and the role of hypoxia-inducible factor-1 in physiological adaptation to hypoxia, neuroprotection and ischemic preconditioning. He has authored or co-authored over 200 research papers and review chapters.